Children's Care Hospital & School, based in Sioux Falls, South Dakota, is the state's only children's hospital. It is a private, non-profit facility licensed by the South Dakota Department of Health. Last year, Children's Care Hospital & School served over 2200 children from birth to age 21 in South Dakota and surrounding states.

Music Therapy Services of South Dakota provides research-based and developmentally appropriate music therapy to children and young adults with disabilities. Services range from indvidual and groups sessions, consulting to programs, workshops and inservices. Specialized music instruction is also offered. Music Therapy and related strategies are provided by a board-certified music therapist and registered state service provider.

The Center for Disabilities is a division of the Department of Pediatrics at The University of South Dakota School of Medicine & Health Sciences. The Center for Disabilities is South Dakota's University Center for Excellence in Developmental Disabilities Education, Research and Service (UCEDDERS) sometimes referred to as University Centers for Excellence in Developmental Disabilities (UCEDD).